An issue has been found with the ISIS System Director (SD) encountering issues after an OS shutdown of Microsoft® Windows Storage Server 2008. Occasionally the ISIS SD fails to restart or fails shortly after restart.  There is no single error to look for.
Products & Versions Affected
ISIS Products:
  • ISIS 7000 & ISIS | 7500 with server hardware running Windows Storage Server 2008 or 2008 R2
  • ISIS  5000 & ISIS | 5500: All capacities
  • ISIS  2000 & ISIS | 2500: All capacities
ISIS versions affected: All versions (when running on Storage Server 2008)

Microsoft Windows Storage Server: 2008 & 2008 R2 (earlier ISIS SDs using Storage Server 2003 is not vulnerable to this issue)

Root Cause
The issue is caused by the Windows Shut down or Restart command not correctly stopping the ISIS SD Service.  

To avoid this issue, stop the System Director Service before rebooting or shutting down the Windows Operating System.   This ensures the ISIS SD service is gracefully shut down, protecting the integrity of metadata and memory structures. The Avid ISIS Engineering team is investigating a software solution to prevent this condition.
Stop the System Director using the System Director Control Panel (or Launch Pad for newer releases of ISIS).  In a redundant System Director configuration, shut down the failover System Director first, then shut down the active System Director. Click the stop button and wait for it to become grayed out and for the start button to turn green.  It is then safe to shut down the active System Director (if any) or reboot the system.

Recommended ISIS Versions
The following ISIS versions are recommended:-

ISIS v4.7.4          Note: v4.2.2 / 4.0.4 is REQUIRED as a transitional step from v2.x & v3.x

ISIS v4.6.1           Note: v4.2.2 / 4.0.4 is REQUIRED as a transitional step from v2.x & v3.x

ISIS v2.4.1           Note: v2.1.2 is REQUIRED as a transitional step from earlier versions

See: link